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KMID : 0369820050350020081
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 2 p.81 ~ p.87
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Current Pretreatment of Skin and Its Effect on the Permeability
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이정화/Lee JH
오승열/Oh SY
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Abstract
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We have prepared karaya gum patches containing ketoprofen and investigated the effect of short-time cur-rent pretreatment of skin on the permeability. Hairless mouse skin was treated with current before the patch was mounted on the skin. The effect of current density and current duration on the flux of ketoprofen was studied. The possibility of additive effect with penetration enhancer (PGML) was also investigated. lontophoretic pretreatment of skin increased the passive flux up to 3 folds at 0.4 mA/cm² current density, when the matrix contained no PGML. As the duration of current-pretreatment and current density increased, flux increased. PGML increased the average passive flux markedly, about 6 to 12 folds, depending on the concentration in the patch. Current pretreatment further increased the flux from this PGML containing patch, exhibiting additive effect. These results indicate that short-duration current pretreatment of skin can be an useful method for the enhancement of ketoprofen permeability through skin.
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KEYWORD
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Ketoprofen, Current-pretreatment, PGML, Flux, Additive effect
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